Pharmacogenomics Biomarker Discovery and Validation for Translation in Clinical Practice
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics in Clinical Practice
The Promise of Pharmacogenomics As genomic medicine advances, there is hope that genetic biomarkers will encourage movement away from empirical and population-based treatment approaches to those that are stratified according to better patient outcomes, thus ending a “trial-and-error” approach to therapy.4,6–8 It is estimated that only 50% of patients respond positively to their medications.5,9 ...
متن کاملBiomarker discovery and validation.
Currently available biomarkers, such as those used to diagnose myocardial infarction (e.g., cardiac troponins), were identified in the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems. Advances in genomics technologies, however, are beginning to permit characterization of global...
متن کاملconstruction and validation of translation metacognitive strategy questionnaire and its application to translation quality
like any other learning activity, translation is a problem solving activity which involves executing parallel cognitive processes. the ability to think about these higher processes, plan, organize, monitor and evaluate the most influential executive cognitive processes is what flavell (1975) called “metacognition” which encompasses raising awareness of mental processes as well as using effectiv...
Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice
The mapping of the human genome and subsequent advancements in genetic technology had provided clinicians and scientists an understanding of the genetic basis of altered drug pharmacokinetics and pharmacodynamics, as well as some examples of applying genomic data in clinical practice. This has raised the public expectation that predicting patients' responses to drug therapy is now possible in e...
متن کاملNeuroimaging-based biomarker discovery and validation.
Although developing biological markers for chronic pain has been a major goal of the field for decades, such biomarkers have not yet made their way into clinical practice. However, given the potential uses of biomarkers in multiple aspects of prevention and treatment—suchaspain and risk factor assessment, diagnosis, prognosis, treatment selection, drug discovery, and more—efforts to discover ne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Translational Science
سال: 2020
ISSN: 1752-8054,1752-8062
DOI: 10.1111/cts.12869